![]() This may involve asking about your drug and alcohol use, risk factors for hepatitis, HIV, and any family history of liver problems. This can lead to yellowing of the skin and eyes, especially during sickle cell crises.įirst, your doctor will ask you some questions to determine the cause of your symptoms. Red blood cells are more fragile in people with sickle cell anemia, so the liver breaks them down more than usual, resulting in more bilirubin. Sickle cell anemia is an inherited disorder that affects the shape of red blood cells. This may cause yellowing of the eyes due to a sudden increase in bilirubin levels. As the malarial parasites damage the red blood cells, the liver produces bilirubin as it breaks the cells down. The parasite travels to the liver, where the infection starts. Malaria spreads to humans through mosquito bites. This is typically a harmless degenerative condition due to chronic exposure to UV radiation, wind, and dust.² Malaria Around 70% of people with pancreatic cancer present with jaundice.¹ PingueculaĪ pinguecula is a small yellow-and-white growth in the eye. This results in components of bile building up in the blood and depositing in the skin and the eyes. The pancreas is below the liver, so inflammation of the pancreas or cancer can block the release of bile from the liver. Other conditions that can cause yellowing of the eyes Pancreatitis or pancreatic cancer This hereditary condition results in excess copper accumulation in the brain and kidneys, but predominantly in the liver. It also means the protein cannot reach its targets in the lungs or elsewhere. In this condition, the protein is not properly built and accumulates in the liver, causing injury to its cells. Your liver makes a protein called AAT to protect the lungs and other parts of the body from a protein secreted by neutrophils that breaks down tissues. This can cause both liver and lung disease. This hereditary disease results in an excess iron build-up in organ tissues, leading to tissue damage. The most common genetic liver conditions include: Hemochromatosis Some viruses, such as hepatitis A and SARS-CoV-2, cause acute disease others, such as hepatitis B and C, cause chronic disease. Alcohol abuse, some medications, and viruses such as hepatitis A, B, C, or SARS-CoV-2 (COVID-19) can cause it. Hepatitis refers to inflammation of the liver. Generally, people remain asymptomatic until the advanced stages of the disease, when cirrhosis sets in. The liver is responsible for processing the alcohol you consume, so excess alcohol consumption can damage the liver and cause inflammation.Īlcoholic liver disease is the most prevalent chronic liver disease globally. Generally, alcoholic liver disease occurs after years of persistently drinking too much or binge drinking. ![]() This damage can progress into end-stage liver disease. Oxidative stress (where free radicals damage cells and contribute to aging) of the liver cells Necrosis (unprogrammed cell death) of liver cells Nonalcoholic fatty liver disease is the most common obesity-related liver disease (NAFLD).Īlthough scientists are unsure of the exact cause, NAFLD seems to be the liver’s display of metabolic syndrome.Īpoptosis (programmed cell death) of liver cells Causes and symptoms of liver diseases Obesity
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